Anushree Chatterjee, Ph.D
Founder Pesident of ARC Laboratories
Dr. Anushree Chatterjee has 15+ years of experience in synthetic and systems biology. She is the inventor of a number of technologies for countering emerging, evolving and drug-resistant pathogens including FAST platform, Quantum dot antibiotics, and CHAOS therapy. . She received her Bachelors and Masters of Technology in Chemical Engineering from Indian Institute of Technology Delhi in 2006. She earned her Ph.D. in Chemical engineering at the University of Minnesota on understanding molecular mechanisms of antibiotic resistance transfer in clinical superbugs in 2011. She was a postdoctoral research fellow at the Theoretical Biology and Biophysics group at Los Alamos National Laboratory studying gene regulation of hepatitis C virus till 2012. In 2013, Anushree joined the faculty at University of Colorado Boulder. She has published 45+ papers in high-impact peer-reviewed journals, given 55 invited talks, and 70+ contributed talks. Anushree has received numerous awards including the DARPA Young Faculty Award, ACS Infectious Diseases Young Investigator Award, New Inventor of the Year award, Provost’s Faculty Achievement award, and the prestigious William M. Keck Foundation grant award. Anushree’s research has been featured by academic and federal institutions such as the Material Research Society, Faculty of 1000, and the National Science Foundation, as well as popular national and international media outlets including BBC, CGTN America, and Voice of America. She has also founded/co-founded two Biotech startup companies, and serves as a board member for COVID- International Research Team. She also serves as an Associate Professor of Chemical and Biological Engineering at the University of Colorado Boulder.

Media

Lab supports COVID-19 International Research Team (COV-IRT) in search of therapeutic solutions against SARS-CoV2


Quantum dot antibiotics could open new front on war against bacteria, CGNT article


Outsmarting Disease with Smart Therapies, American Physical Society



COVID-19: ACE, Targeted Therapies, Old & New Medicines, How on Earth - The KGNU Science Show, listen here


Six grand ideas to fight the end of antibiotics, BBC article

Selected Publications





Thomas R. Aunins, Keesha E. Erickson, Anushree Chatterjee* (2020). Transcriptome-based design of antisense inhibitors re-sensitizes CRE E. coli to carbapenems. Proceedings of the National Academy of Sciences (In press).

Thomas R. Aunins, Kristen A. Eller, Colleen M. Courtney, Max Levy, Samuel M. Goodman, Prashant Nagpal, and, Anushree Chatterjee* (2019). Isolating the Escherichia coli transcriptomic response to superoxide generation from cadmium chalcogenide quantum dots. ACS Biomaterials Science and Engineering 5(9), 4206-4218.  

Peter B. Otoupal, William T. Cordell, Vismaya Bachu, Madeleine J. Sitton and Anushree Chatterjee* (2018). Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis. Nature Communications Biology 1:129. doi: 10.1038/s42003-018-0135-2

Thomas R. Aunins, Katherine A. Marsh, Gitanjali Subramanya, Susan L. Uprichard, Alan S. Perelson, and Anushree Chatterjee* (2018). Intracellular hepatitis C modeling predicts infection dynamics and viral protein mechanisms. Journal of Virology 92(11) e02098-17. doi:10.1128/JVI.02098-17

Thomas R. Aunins, Keesha E. Erickson, Nripesh Prasad, Shawn E. Levy, Angela Jones, Shristi Shrestha, Rick Mastracchio, Louis Stodieck, David Klaus, Luis Zea*, Anushree Chatterjee* (2018). Spaceflight modifies Escherichia coli gene expression in response to antibiotic exposure and reveals role of oxidative stress. Frontiers in Microbiology 9:310. doi: 10.3389/fmicb.2018.00310

Keesha E. Erickson, James D. Winkler, Danh T. Nguyen, Ryan T. Gill, and Anushree Chatterjee* (2017). The Tolerome: A database of transcriptome-level contributions to diverse Escherichia coli resistance and tolerance phenotypes. ACS Synthetic Biology 6 (12), pp 2302–2315. DOI: 10.1021/acssynbio.7b00235. Link to database.

Keesha E. Erickson, Peter B. Otoupal, and Anushree Chatterjee* (2017). Transcriptome level signatures in gene expression and gene expression variability during bacterial adaptive evolution. mSphere 2:e00009-17. DOI: 10.1128/mSphere.00009-17

Peter B. Otoupal, Keesha E. Erickson, Antoni E. Bordoy, and Anushree Chatterjee* (2017). "CRISPR perturbation of gene expression alters bacterial fitness under stress and reveals underlying epistatic constraints." ACS Synthetic Biology  6 (1), pp 94–107. DOI: 10.1021/acssynbio.6b00050.

Colleen M. Courtney, Samuel Goodman, Toni Nagy, Max Levy, Pallavi Bhusal, Nancy E. Madinger, Corrella Detweiler, Prashant Nagpal*, and Anushree Chatterjee* (2017). Potentiating clinical drug resistant bacteria via stimuli-activated superoxide generation. Science Advances 3:e1701776. DOI: 10.1126/sciadv.1701776

Colleen M. Courtney#, Samuel Goodman#, Jessica Mc Daniel, Nancy Madinder, Anushree Chatterjee*, and Prashant Nagpal* (2016). "Photoexcited Quantum Dots for Killing Multi-Drug Resistant Bacteria." Nature Materials 15, 529-534. DOI: 10.1038/nmat4542 (Link)



All Publications and Patents